| Source DB | nl |
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| Institution | KU Leuven |
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| Code | 24101eb1-a746-4af2-8754-919e95f165dc |
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| Unit | b9b3c61e-650e-4463-a0e2-6de8f49917ba
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| Begin | 1/1/2018 |
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| End | 12/31/2021 |
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| title fr |
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| title nl | Ontwikkeling en gebruik van een geïntegreerd in silico-in vitro mesofluidics systeem voor weefselengineering
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| title en | Development and use of an integrated in silico – in vitro mesofluidics system for tissue engineering
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| Description fr |
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| Description nl | Het INSITE-project wil beide uitdagingen aanpakken door gebruik te maken van een nieuwe mesofluidics-opzet voor in vitro testen van TE-constructies en door speciale multischalige en multiphysische modellen te ontwikkelen die de beschikbare gegevens aggregeren en deze gebruiken om complexe constructen te ontwerpen.
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| Description en | Tissue Engineering (TE) refers to the branch of medicine that aims to replace or regenerate functional tissue or organs using man-made living implants. As the field is moving towards more complex TE constructs with sophisticated functionalities, there is a lack of dedicated in vitro devices that allow testing the response of the complex construct as a whole, prior to implantation. Additionally, the knowledge accumulated from mechanistic and empirical in vitro and in vivo studies is often underused in the development of novel constructs due to a lack of integration of all the data in a single, in silico, platform. The INSITE project aims to address both challenges by exploiting a new mesofluidics set-up for in vitro testing of TE constructs and by developing dedicated multiscale and multiphysics models that aggregate the available data and use these to design complex constructs. The combination of these in silico and in vitro approaches will lead to an integrated knowledge-rich mesofluidics system that provides an in vivo-like time-varying in vitro environment. A proof of concept will be delivered for complex TE constructs for large bone defects. If successful, the INSITE system will allow for a maximum of relevant in vitro research prior to the in vivo phase, which is highly needed in academia and industry with the increasing ethical (3R), financial and regulatory constraints.
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| Qualifiers | - In vitro - Mesofluidics - Tissue Engineering - |
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| Personal | Geris Liesbet |
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