| Source DB | nl |
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| Institution | KU Leuven |
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| Code | 79170013-934e-46e8-a349-f7c1c3c3f3fb |
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| Unit | b9b3c61e-650e-4463-a0e2-6de8f49917ba
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| Begin | 1/1/2017 |
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| End | 1/31/2020 |
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| title fr |
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| title nl | Ontrafelen van de rol van cel-ECM
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| title en | Unraveling the Role of Cell-ECM
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| Description fr |
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| Description nl | We stellen voor een multischaal rekenmodel te ontwikkelen dat celherschikkingen in een spruit kan modelleren. Door microscopie met hoge resolutie te gebruiken, kunnen we bewegingen van cellen en extracellulaire componenten in een collageengel berekenen om de door cellen uitgeoefende krachten te verkrijgen en informatie over cellulaire toebehoren aan de omgeving. De resultaten van deze studie kunnen worden toegepast op weefseltechnologie, celmigratiestudies, ontwikkelingsbiologie en kankerbiologie.
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| Description en | The mechanism by which multiple cells form patterns remains partly unknown. It is important during development, in which cells start as identical in a rounded embryo and move and differentiate to form all tissues and organs. Many experiments have revealed the importance of chemical signals as well as mechanical forces in directing cell behavior and resulting in this pattern formation. Angiogenesis, the formation of blood vessels from existing ones, provides a good model system; in its first steps few cells leave a larger population for form a sprout. We propose developing a multiscale computational model that can model cell rearrangements in a sprout. By using high resolution microscopy, we can calculate movements of cells and extracellular components in a collagen gel to obtain the forces exerted by cells and information on cellular attachments to surroundings. Experimental results will be used to validate the model, thus gaining insight into current processes that cannot be quantified experimentally such as cell-cell adhesion regulation and individual cell protein expression. The results of this study can be applied to tissue engineering, cell migration studies, developmental biology, and cancer biology.
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| Qualifiers | - cel-ECM - |
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| Personal | Vargas Arango Diego, Van Oosterwyck Hans |
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